Unfortunately, about 1 in 5 conﬁrmed pregnancies end in a miscarriage during the ﬁrst trimester. One in two hundred couples will experience two or more consecutive miscarriages. The possible reasons for recurrent miscarriage are:
• 1% Infection
• 5-10% Abnormal anatomy
• 7% Abnormal chromosomes
• 15% Hormonal factors
• 20% Unknown
• 50% Immune mechanisms
Some woman can have multiple reasons for miscarriage.
The immune mechanisms play a big role in the miscarriage problematic and the recurrent fertility treatment failure. The important part of immune system are white blood cells, also known as leukocytes, which produce a variety of antibodies. These are meant to protect us, doing so by recognising foreign antigens (= foreign substances from the environment, such as bacteria, viruses), which enables the immune system to destroy them. Some of these antibodies can be harmful to our bodies. As an example of the damaging ones involved in the reproductive system are antiphospholipid antibodies and antinuclear antibodies, which we routinely test when fertility issues occur.
When the immune system is the cause of miscarriage, the chances of the mother having a successful pregnancy after 3 miscarriages without treatment such as Intralipid or/and intravenous immunoglobulin (IVIG) is 30%, after 4 miscarriages 25% and after 5 only 5%. With the proper treatment, the overall success is 80%.
We are a specialised clinic treating women with recurrent spontaneous miscarriages, recurrent implantation failure and immune related infertility. We offer Intralipid, intravenous immunoglobulin (IVIG) treatment and advanced hysteroscopy and laparoscopy surgeries tailored to woman’s individual case. Dr Saba may collaborate with the woman’s IVF centre of choice when immune treatments are needed.